Skin capacitance mapping of psoriasis

Background  The pathobiological dynamics of psoriatic lesions are complex and difficult to perceive by clinical inspection alone. Non‐invasive bioengineering methods may prove to be useful in this field. Objective  To identify some subtle capacitance variations in the stratum corneum of chronic psoriasis lesions. Method  The newly developed method of skin capacitance imaging was used to provide non‐optical images of the hydration of the superficial layers of the stratum corneum. Results  Compared to the uninvolved skin, psoriatic lesions usually showed an overall lowered capacitance, admixed with foci of moderately higher capacitance. Still other sharply circumscribed blotches with higher capacitance were present. The latter aspect corresponded to inflammatory areas. Sweating appeared markedly impaired inside the lesions. The fingerprint of some patients was altered, thus potentially interfering with the current biometric security procedures using the same method. Conclusion  Skin capacitance imaging is a non‐invasive, non‐optical method that distinguishes three contrasting levels of stratum corneum hydration in psoriatic lesions. The lowest capacitance level probably corresponded to xerotic orthokeratosis. The medium capacitance level presumably identified foci of parakeratosis and clumps of neutrophils. The highest capacitance level suggested exsudation at the site of prominent vessel dilation and dermal inflammation. Impaired sweating in the psoriatic lesions may potentially interfere with body thermoregulation.