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Cutaneous hyperpigmentation induced by omeprazole mimicking ashy dermatosis
Author(s) -
RamírezHernández M,
MartínezEscribano JA,
MartínezBarba E,
AlcoleaRubio LA,
IbarraBerrocal IJ
Publication year - 2006
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2006.01484.x
Subject(s) - hyperpigmentation , omeprazole , dermatology , skin biopsy , biopsy , medicine , trunk , adverse effect , pathology , biology , ecology
Abstract Background Omeprazole has been associated with multiple adverse effects including skin reactions but, to date, cutaneous hyperpigmentation has not been described as an adverse effect of this drug. Observations We describe a case of a 52‐year‐old Caucasian woman who developed skin hyperpigmentation in the upper trunk, mimicking ashy dermatosis, 2 months after initiating omeprazole treatment. Histopathologic examination of a skin biopsy taken from a pigmented macule showed dermal macrophages containing golden‐brown granules, which also displayed a sulphur peak on energy‐dispersive X‐ray microanalysis. High‐performance liquid chromatography (HPLC) and mass spectrometry were also performed on the drug and on a biopsy specimen revealing the same chromatograms as well as the same mass spectra. Conclusions According to our results, omeprazole itself may induce cutaneous pigmentation and, to our knowledge, this is the first report of this finding.