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Peripheral insulin resistance in patients with Behçet's disease
Author(s) -
Erdem H,
Dinc A,
Pay S,
Simsek I,
Turan M
Publication year - 2006
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2006.01457.x
Subject(s) - medicine , insulin resistance , erythrocyte sedimentation rate , endothelial dysfunction , endocrinology , insulin , peripheral , glucose clamp technique , inflammation , diabetes mellitus , c reactive protein , gastroenterology , pancreatic hormone
In this study, we examined peripheral insulin resistance in patients with Behçet's disease (BD) characterized by chronic inflammation and endothelial dysfunction. Fourteen patients with BD and 15 healthy controls were recruited to the study. Insulin resistance was investigated by the hyperinsulinaemic–euglycaemic glucose clamp technique. BD patients displayed an enhanced rate of insulin resistance compared to healthy controls ( P = 0.014). The insulin sensitivity ( M ), measured as the glucose utilization rate under steady‐state conditions of euglycaemia, was significantly decreased ( P = 0.001) in BD patients compared to the controls (4.09 ± 0.16 vs. 5.60 ± 0.27 mg/kg/min). The C‐reactive protein (CRP) level, but not the erythrocyte sedimentation rate (ESR), was significantly related to the presence of insulin resistance (CRP: r s = 0.589, P = 0.27; ESR: r s = 0444, P = 0112), whereas no relationship was found between the M ‐value and ESR or CRP. We conclude that patients with BD exhibit peripheral insulin resistance; this could be explained as the diverse consequences of inflammation and endothelial dysfunction in BD.