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Primary Gougerot–Sjögren syndrome: a dermatological approach
Author(s) -
Roguedas AM,
Youinou P,
Lemasson G,
Pennec YL,
Misery L
Publication year - 2006
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2006.01441.x
Subject(s) - medicine , sjögren syndrome , pseudolymphoma , dermatology , vasculitis , keratoconjunctivitis sicca , autoimmune disease , pathology , lymphocytic infiltration , disease , lymphoma , immunology
Gougerot–Sjögren syndrome (GSS) is a chronic heterogeneous non‐organ‐specific autoimmune disease, encompassing a wide spectrum of clinical manifestations. It is characterized by a lymphocytic infiltration of the exocrine glands, also called epitheliitis, resulting in xerostomia and keratoconjunctivitis sicca. The skin can also be involved; for example, xerosis is a consequence of epitheliitis. Dermatological consequences of polyclonal reactivity are vasculitis and manifestations of B‐cell proliferation vary from plasma cell infiltrates to B‐cell lymphoma.