Premium
Minocycline‐induced cutaneous hyperpigmentation: confocal laser scanning microscope analysis
Author(s) -
DodiukGad RP,
Morentin HM,
Schafer J,
Harel A,
Neudorfer M,
Misonzhnik F,
Gitstein G,
Rozenman D,
Tur E,
Brenner S
Publication year - 2006
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2006.01436.x
Subject(s) - minocycline , hyperpigmentation , medicine , confocal , dermatology , fluorescence , confocal microscopy , skin type , pathology , optics , chemistry , physics , antibiotics , biochemistry
Background Minocycline has a characteristic yellow‐green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline‐induced skin hyperpigmentation. Objective To investigate whether the fluorescence can be detected in other types of minocycline‐induced cutaneous hyperpigmentation, and to study the possible mechanisms. Methods Biopsies of pigmented and nonpigmented skin from 3 patients with different types of skin hyperpigmentation induced by minocycline were analysed by light microscopy and Confocal Laser Scanning Microscope (CLSM). Results A yellow‐green fluorescence was observed in the hyperpigmented skin of two patients with type 2, and one patient with type 4 minocycline–induced cutaneous hyperpigmentation. No fluorescence was detected in the non‐pigmented skin. Conclusion Minocycline can possibly serve as a fluorescent probe in the diagnosis of all types of minocycline‐induced cutaneous hyperpigmentation.