Premium
Healing effect of ketanserin on chronic leg ulcers in patients with diabetes
Author(s) -
Quatresooz P,
Kharfi M,
Paquet P,
Vroome V,
Cauwenbergh G,
Piérard GE
Publication year - 2006
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2006.01422.x
Subject(s) - medicine , ketanserin , placebo , diabetes mellitus , wound healing , surgery , diabetic foot , placebo group , serotonin , 5 ht receptor , receptor , pathology , alternative medicine , endocrinology
Background The treatment of chronic leg ulcers remains a stubborn problem in many patients. Topical 2% ketanserin ointment, a 5HT 2 ‐serotoninergic blocking agent, has been reported to improve healing of decubitus, venous, diabetic and ischaemic ulcers. Method The present double‐blind intra‐individual comparative study was performed in 12 women with diabetes presenting with at least two similar leg ulcers. In each subject, the two lesions were randomly assigned to be treated for 8 weeks by 2% ketanserin ointment or its unmedicated vehicle. Objective assessments of the dynamics of wound healing were performed using computerized morphometry. Evaluations were performed at 2‐week intervals for 8 weeks. Results A significant decrease in relative wound area was observed on the ketanserin‐treated ulcers compared with the placebo group. Conclusion Topical ketanserin is a valuable therapy for difficult‐to‐treat leg ulcers.