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Apolipoprotein E polymorphism and lipoprotein compositions in normolipidaemic xanthelasma patients
Author(s) -
Tursen U,
Eskandari G,
Kaya Ti,
Tamer L,
Ikizoglu G,
Atik U
Publication year - 2006
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2006.01418.x
Subject(s) - apolipoprotein e , apolipoprotein b , lipoprotein , medicine , triglyceride , genotype , allele , cholesterol , apolipoprotein c2 , polymorphism (computer science) , endocrinology , very low density lipoprotein , genetics , biology , gene , disease
Background Apolipoprotein E (apoE) phenotypes and lipoprotein compositions in xanthelasma patients have been reported in different series. Objective To investigate the apoE polymorphism and lipoprotein compositions in xanthelasma patients by using rapid polymerase chain reaction, and searched for an association between apoE polymorphism and the lipoprotein levels in xanthelasma patients. Design ApoE polymorphism and the different types of serum lipoproteins were studied in 25 patients with xanthelasma and compared with 27 normal subjects. Results All of patients were found to be normolipidaemic. The patients had significantly higher concentrations of total cholesterol and apolipoprotein B, and lower concentrations of apolipoprotein A. There was no difference in serum triglyceride, low‐density lipoprotein (LDL) and high‐density lipoprotein (HDL) cholesterol concentrations. The distribution of apoE genotypes and alleles was the same in both groups. Conclusions The apoB, apoA and cholesterol levels did show statistically significant differences in the direction of an increased risk of atherosclerosis. Patients with xanthelasma demonstrated slight differentiations in the apoE polymorphism and metabolism of lipoproteins that require further clarifications.