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Localized Kaposi's sarcoma in a patient with pemphigus vulgaris
Author(s) -
AvalosPeralta P,
Herrera A,
RíosMartín JJ,
PérezBernal AM,
MorenoRamírez D,
Camacho F
Publication year - 2006
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2005.01348.x
Subject(s) - pemphigus vulgaris , medicine , prednisone , sarcoma , dermatology , polymerase chain reaction , mycophenolate , kaposi's sarcoma , virology , human herpesvirus , pathology , surgery , transplantation , gene , biochemistry , chemistry
We report the case of a patient with a 13‐year history of pemphigus vulgaris (PV) treated with immunosuppressive agents, prednisone and mycophenolate mofetil who had developed lesions of Kaposi's sarcoma (KS) on a sole plaque of PV that had been previously treated with intralesional injections of steroids. The lesions were surgically removed and polymerase chain reaction (PCR) demonstrated human herpesvirus‐8 (HHV‐8) DNA. There were neither recurrences nor later dissemination of KS following gradual decrease of the immunosuppressive therapy. We suggest that the treatment with intralesional steroids may have influenced the local reactivation of a latent infection of the virus, determining the appearance of this localized KS.