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Alopecia areata treatment with a phototoxic dose of UVA and topical 8‐methoxypsoralen
Author(s) -
Mohamed Z,
Bhouri A,
Jallouli A,
Fazaa B,
Kamoun MR,
Mokhtar I
Publication year - 2005
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2005.01226.x
Subject(s) - alopecia areata , medicine , dermatology , erythema , psoralen , alopecia universalis , phototoxicity , methoxsalen , scalp , hair growth , puva therapy , psoriasis , physiology , dna , biochemistry , genetics , chemistry , in vitro , biology
Twenty‐five patients with alopecia totalis (AT) or alopecia universalis and 124 patients with alopecia areata (AA) were treated with photochemotherapy, combining topical 8‐methoxypsoralen (8‐MOP) with UV irradiation of the scalp at a phototoxic dose. The mean energy required was 15 J/cm 2 for AA and 42 J/cm 2 for AT. Ninety‐four patients had multiple bald patches and 12 with AT had complete or > 50% hair regrowth. Positive treatment results did not seem to depend on the age of onset or the duration of the disease. Few side‐effects of topical psoralens plus UVA (PUVA) treatment were noted, except a for few days of slight erythema caused by the high dose of UV.