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Persistent serpentine supravenous hyperpigmented eruption associated with docetaxel
Author(s) -
Aydogan I,
Kavak A,
Parlak AH,
Alper M,
Annakkaya AN,
Erbas M
Publication year - 2005
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2005.01088.x
Subject(s) - medicine , docetaxel , forearm , dermatology , mucocutaneous zone , vein , drug eruption , common terminology criteria for adverse events , surgery , chemotherapy , pharmacology , disease , drug
Various mucocutaneous reactions have been reported with the use of systemic docetaxel. We describe a 47‐year‐old man who developed a persistent serpentine supravenous hyperpigmented eruption (PSSHE), beginning at the site of docetaxel injection and spreading along the superficial venous network in the anterior aspect of the right forearm and distal arm. The eruption occurred after the first infusion of docetaxel following insufficient venous washing. A second infusion was administered through a vein in the other forearm, but this time, abundant venous washing was performed and a similar eruption did not occur. To our knowledge, this is the second report of docetaxel‐induced supravenous discoloration and we discussed the terminology and mechanism of this unique reaction.