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Keratosis lichenoides chronica and eruptive keratoacanthoma‐like lesions in a patient with multiple myeloma
Author(s) -
Marzano AV,
Bellinvia M,
Caputo R,
Alessi E
Publication year - 2005
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2004.01112.x
Subject(s) - medicine , acitretin , keratoacanthoma , dermatology , keratoderma , dyskeratosis , pathology , hyperkeratosis , psoriasis , basal cell
We describe a 72‐year‐old woman with a 13‐year history of a lichenoid dermatitis, who developed multiple, papular keratoacanthoma (KA)‐like lesions and few crater‐like nodules on the extremities over a period of 6 months before our observation. Her medical history also recorded multiple myeloma diagnosed a few years before. The long‐standing dermatosis was diagnosed, clinically, as keratosis lichenoides chronica (KLC), although, histologically, a lichenoid tissue reaction pattern was not evident. On the other hand, histology from papular and nodular lesions of recent onset was consistent with a possible early phase of KA and spinocellular carcinoma, respectively. Oral acitretin induced regression of KA‐like lesions and improvement of KLC but had no effects on crater‐like nodules, which required surgical excision. KLC is a chronic disorder of keratinization characterized by lichenoid hyperkeratotic papules arranged in a linear pattern, erythematosquamous plaques and seborrhoea‐like dermatitis. We emphasize in our case the association between KLC and multiple possible KAs, never previously reported, and speculate that these two rare conditions may represent here a ‘continuum’ from a pathogenetic point of view.