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Pyoderma gangrenosum with spleen involvement and monoclonal IgA gammopathy
Author(s) -
Mijuşković Z̆P,
Zečević RD,
Pavlović MD
Publication year - 2004
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2004.01031.x
Subject(s) - medicine , pyoderma gangrenosum , prednisone , monoclonal gammopathy , pyoderma , spleen , hypergammaglobulinemia , dermatology , gastroenterology , monoclonal , surgery , monoclonal antibody , immunology , antibody , disease
A 46‐year‐old man with a 3‐year history of pyoderma gangrenosum was admitted with ulceration (6 × 5 cm), on the right leg. Previously he had been treated with tapering doses of prednisone (maximum dose 1 mg/kg per day); however, he had had a few exacerbations following each taper of prednisone dose. Immunoelectrophoresis demonstrated monoclonal IgA gammopathy of λ light chains. Abdominal echography and abdominal computed tomographic scan revealed multiple splenic abscesses. Treatment was started with oral prednisone (1 mg/kg per day) and cyclosporin (5 mg/kg per day) and 6 weeks later complete remission was achieved. Systemic involvement in pyoderma gangrenosum is very rare, and according to our knowledge there are only a few cases with spleen involvement.