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Lisch nodules of the iris in neurofibromatosis type 1
Author(s) -
Richetta A,
Giustini S,
Recupero SM,
Pezza M,
Carlomagno V,
Amoruso G,
Calvieri S
Publication year - 2004
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2004.00915.x
Subject(s) - medicine , neurofibromatosis , nodule (geology) , neurofibroma , pathology , hamartoma , iris (biosensor) , dermatology , biology , paleontology , computer security , computer science , biometrics
Neurofibromatosis type 1 (NF1) is a common autosomal dominant disease. The Lisch nodule represents one of the most common NF1 ocular manifestations. Several studies have reported that the Lisch nodule is a melanocytic hamartoma but its pathogenesis is still debated. We have studied the histopathological and ultrastructural features of a Lisch nodule of a 50‐year‐old woman biopsied during an intracapsular cataract extraction. Our researches revealed that it was composed of three main cytotypes: pigmented cells, fibroblast‐like cells and mast cells, showing a pattern similar to a neurofibroma. Furthermore, we hypothesize that Lisch nodules are compatible with neurofibromas.