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Maculopapular eruption with enlarged macrophages in eight patients receiving G‐CSF or GM‐CSF
Author(s) -
ÁlvarezRuiz S,
Peñas PF,
FernándezHerrera J,
SánchezPérez J,
Fraga J,
GarcíaDíez A
Publication year - 2004
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2004.00872.x
Subject(s) - medicine , granulocyte macrophage colony stimulating factor , pathology , granulocyte , presentation (obstetrics) , biopsy , immunology , cytokine , surgery
ABSTRACT In the last years, granulocyte and granulocyte‐macrophage colony‐stimulating factors (G‐CSF and GM‐CSF) are being increasingly used and several cutaneous eruptions have been reported in relation to these treatments. In 1991 Horn et al . described three patients with maculopapular eruption that paralleled the time of infusion of GM‐CSF. Two of the cases showed an increase in the number and size of macrophages in the biopsy specimen. Since then, several cases have been reported showing this histopathological alteration that has been considered characteristic of reaction to G‐CSF or GM‐CSF. Although maculopapular eruption with enlarged macrophages can appear after chemotherapy treatment, we have found that the presentation of this eruption after the beginning of cytokine treatment is suggestive of the involment of G‐CSF and GM‐CSF in the eruption. We described eight cases of patients treated with G‐CSF or GM‐CSF that developed maculopapular eruptions with enlarged macrophages.