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Mid‐dermal elastolysis associated with Hashimoto's thyroiditis
Author(s) -
Gambichler Thilo,
Linhart Carola,
Wolter Manfred
Publication year - 1999
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.1999.tb01038.x
Subject(s) - medicine , thyroiditis , pathology , asymptomatic , thyroid , dermis , anti thyroid autoantibodies , autoantibody , dermatology , immunology , antibody , disease
We report the case of a 38‐year‐old Caucasian female presenting asymptomatic plaques of fine wrinkling and perifollicular papular protrusions especially on the trunk. Histological examination evidenced loss of elastic fibers in the mid‐dermis due to elastophagocytosis, with giant cells and granuloma formation. Moreover, elevated titers of thyroid autoantibodies were detected and thyroid ultrasound revealed echo‐poor tissue. These findings met the diagnoses of mid‐dermal elastolysis and Hashimoto's thyroiditis. This association has not been reported before. We present a comprehensive overview of the literature and discuss the pathogenetic aspects of mid‐dermal elastolysis and the significance of the association with Hashimoto's thyroiditis.