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Mastocytosis with skin manifestations: current status
Author(s) -
Katsambas Andreas D.,
Karpouzis Anthony J.,
KoumantakiMathioudaki Elma,
Jorizzo Joseph L.
Publication year - 1999
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.1999.tb00878.x
Subject(s) - medicine , disease , biopsy , bone marrow , dermatology , pathology , skin biopsy , progenitor cell , lesion , urticaria pigmentosa , inflammation , immunology , stem cell , biology , genetics
Aim To review our present knowledge about mastocyte origin, mastocytosis classification and management. Methods Literature review. Results Mastocytoses are chronic and recurrent disorders with symptoms which might either be limited only to the skin or to internal organs as well. The mastocytes, coming from bone marrow progenitor cells, migrate to tissues where they participate in inflammation and in cellular immunity as well as in the metabolism of connective and osseous tissues. Their proliferation causes the appearance of mastocytoses. The classification of the clinical manifestations of the mastocytoses into cutaneous, reactive (under the influence of the degranulator factors) and systemic disease, facilitates dialog among clinicians. Determination of prognosis and appropriate therapeutic regimens depend on individual features. Conclusions Mastocytosis diagnosis is verified by histological study of skin lesion biopsy material. Management is symptomatic and unfortunately does not eradicate the disease.