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Antibodies to desmoplakin in a patient with pemphigus foliaceous
Author(s) -
Jiao Diane,
Bystryn JeanClaude
Publication year - 1998
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.1998.tb00774.x
Subject(s) - pemphigus , medicine , desmoplakin , paraneoplastic pemphigus , erythema multiforme , antibody , bullous pemphigoid , dermatology , autoantibody , pathology , immunology , genetics , cell , biology
Background Antibodies to desmoplakins have been associated with paraneoplastic pemphigus. Here, we report a case of non‐neoplastic pemphigus foliaceous with antibodies to desmoplakins. Observation A 61‐year‐old woman with pemphigus foliaceous by clinical, histological and immunofiuorescent criteria was found to have circulating antibodies to 250 and 215 kDa antigens identified as desmoplakin I and II by immunoblotting and immunoprecipitation. The patient had no evidence of cancer during a follow‐up period of 3 years. Conclusion Although antibodies to desmoplakin I and II have previously been associated with paraneoplastic pemphigus, their occasional finding in erythema multiforme and bullous pemphigoid indicates that they can also occur in non‐neoplastic pemphigus.