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Multiple painful leiomyomas of the skin: a novel therapy with sympathicolysis?
Author(s) -
Hauschild Axel,
Maier Christoph,
Christophers Enno
Publication year - 1997
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.1997.tb00515.x
Subject(s) - medicine , leiomyoma , vasoconstriction , smooth muscle , uterine leiomyoma , vasodilation , cutis , disease , leiomyomatosis , surgery , dermatology , pathology , anesthesia
Leiomyomatosis cutis is a rare disease involving large areas of the body surface with painful leiomyomas. Only a small panel of drugs has provided limited effects in the management of paroxysmal pain attacks associated with these tumours. Two patients with multiple, otherwise therapy‐refractors cutaneous leiomyomas predominantly on the extremities underwert experimental transient sympathicolysis. Experimental cold exposure and noradrenulin injections resulted in increasing pain and vasoconstriction. whereas sympathicolysis counteracted this with pain reduction and vasodilatation. Our results confirm that α‐adrenergic fibres play an important role in smooth muscle contraction and pain induction in cutaneous leiomyomas. Sympathicolysis should be induced in the therapeutic choices available for multiple painful leiomyomas localized on the extremities.