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A survey of reactive oxygen species and their role in dermatology
Author(s) -
Maccarrone Mauro,
Catani Maria Valeria,
Iraci Stefano,
Melino Gerry,
Agrò Alessandro Finazzi
Publication year - 1997
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.1997.tb00478.x
Subject(s) - reactive oxygen species , medicine , antioxidant , human skin , bioinformatics , computational biology , microbiology and biotechnology , biochemistry , biology , genetics
General description It this paper we present a survey of the main reactive oxygen species (ROS). their biological sources and the array of antioxidant enzymes and antiradical molecules which constitutes the cellular detent; against ROS toxicity. We outline also the fundamentals of ROS biochemistry, in relation to the role of ROS in several human pathologies. Finally, we discuss with particular emphasis the involvement of ROS in dermatological diseases, highlighting the possible therapeutic application of antioxidants in skin care. Learning objective The reader will learn what ROS are, the identity of the anti‐ROS defensive system in human cells and the many fold roles of ROS in human physiopathology, and thus the potential application of antioxidants in clinical therapy.