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Serum level of major basic protein indicates disease activity in atopic dermatitis
Author(s) -
Ikai Kouichi,
Nakajima Naoko,
Ozaki Motoaki,
Furukawa Ikuko,
Aoshima Toshiyuki,
Mitani Tsuneo,
Sawami Mari,
Sayama Shigetoshi,
Omoto Mitsuyoshi,
Uehara Masami,
Imamura Sadao
Publication year - 1997
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.1997.tb00228.x
Subject(s) - medicine , ketotifen , atopic dermatitis , eosinophil , radioimmunoassay , major basic protein , immunology , asthma
We evaluated the serum levels of major basic protein (MBP), assayed using an MBP radioimmunoassay kit. and the effect of an anti‐allergic agent, ketotifen, which has strong anti‐eosinophil activity, in 56 atopic dermatitis (AD) patients. The serum MBP level was significantly lower (660.11 ± 34.52 ng/ml, P < 0.05) after administration of ketotifen (1 mg twice a day) for 8 weeks than before treatment (774.98 ± 48.64 ng/ml). These findings suggest that serum MBP levels are a useful indicator of AD activity and that anti‐allergic agents can have an effect on eosinophil involvement in AD.