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Analysis of the antifungal activity of ketoconazole, zinc pyrithione, and ciclopirox olamine against Pityrosporum ouale. A diffusion assay for cultures in solid media
Author(s) -
Squiquera Luis,
Plotkin Lilian,
Mathov Irina,
Galimberti Ricardo,
Leoni Juliana
Publication year - 1996
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.1996.tb00552.x
Subject(s) - ketoconazole , dandruff , pharmacology , antifungal , medicine , malassezia , itraconazole , shampoo , dermatology , pathology
Background Recently dandruff has been associated with a local increment in the number of Pityrosporum yeasts. Due to this fact, several anti‐dandruff shampoos containing antifungals have been marketed. Objective We studied the sensitivity of Pityrosporum ovale (PO) to three different groups of antimycotics (ketoconazole, Zn pyrithione, and ciclopirox olamine). Methods /Results The drugs were tested by an inhibition assay in solid medium. Ketoconazole proved to be the most effective drug in inhibiting PO growth in a dose‐dependent fashion. The results of our evaluation revealed that the inhibitory effects of the drugs were ketoconazole > Zn pyrithione > ciclopirox olamine. Conclusion We postulate that the diffusion assay is a reliable medium for evaluating the effectiveness of antifungals contained in anti‐dandruff shampoos.