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Cutaneous lymphadenoma is distinct from basal cell carcinoma
Author(s) -
Krahl Dieter,
Kohl Peter Karl
Publication year - 1996
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.1996.tb00132.x
Subject(s) - peanut agglutinin , basal cell carcinoma , pathology , medicine , lymphoepithelioma , immunohistochemistry , histology , staining , eyebrow , agglutinin , basal (medicine) , basal cell , anatomy , lectin , radiation therapy , nasopharyngeal carcinoma , immunology , surgery , insulin
Background Cutaneous lymphadenoma is a recently recognized unusual tumor. It presents as an indistinct solitary non‐ulcerating dermal nodule occuring mostly in the head and neck region of middle aged persons. Its histogenetic definition is controversial and recently it has been proposed that it might represent an unusual inflammatory basal cell carcinoma. We present clinical, hislological and immunohistochemistry data of two cases. For the first time lectin‐imrnunohistochemisiry of cutaneous lymphadenoma is reported on. Observations One tumor was located on the eyebrow of a 37 years old, the other on the nose of a 75 years old male patient. Slow growth over years occured. Histology showed biphasic pattern of elongated and angulated lobules with peripheral rim of basaloid cells and central network of lymphohisltocytic cells with preponderance of protein S 100‐positive cells. Peanut agglutinin (PNA) did not show peripheral staining around tumor lobules as seen in basal cell carcinoma. Conclusions Clinical and histological features as well as absence of peanut agglutinin staining argue in favor of the distinction of cutaneous lymphadenoma from inflammatory basal cell carcinoma. The former probably represents a benign growth of adnexal origin.