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Axillary hyperpigmentation with 5‐fluorouracil/ cis ‐platinum combination therapy
Author(s) -
Thomas P.,
Kind P.,
Dathe O.,
Ruzicka Th.
Publication year - 1995
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.1995.tb00431.x
Subject(s) - medicine , hyperpigmentation , carboplatin , fluorouracil , dermatology , adverse effect , chemotherapy , cisplatin
Adverse reactions to chemotherapeutic drugs are usually classified as cytotoxic reactions, hypersensitivity phenomena or reactions related to immunomodulatory drugs. We present a patient with patterned hyperpigmentation in both axillary regions after 5‐fluorouracil/carboplatin combination therapy. From the cutaneous aspect and the histological examination we suspect that this was caused by a toxic effect of the drugs excreted in the sweat. The occluding condition of the axillary region may have acted as aggravating factor.