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Increased prevalence of herpes viruses in high grade CIN and carcinoma of the cervix: the potential for synergistic effect ⋆
Author(s) -
Baldauf JJ.,
Dreyfus M.,
Monlun E.,
Ritter J.,
Obert G.
Publication year - 1995
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.1995.tb00298.x
Subject(s) - medicine , colposcopy , cervical intraepithelial neoplasia , herpes simplex virus , cervix , cervical cancer , cytomegalovirus , human papillomavirus , gynecology , virology , cancer , oncology , herpesviridae , virus , viral disease
Objective To assess the prevalence of human papillomavirus (HPV) type 16 and 18, herpes simplex virus (HSV) and human cytomegalovirus (HCMV) in cervical biopsies in order to evaluate their relationship in cervical intraepithelial neoplasia (CIN) and cancer. Setting Colposcopy clinic; Service de Gynécologic‐Obstétrique I, Hôpital de Hautepierre. Hôpitaux Universities de Strasbourg and Laboratoire Commun ULP/Synthélabo et U74 INSERM. Institut de Virologie dc la Faculté de Medecine de Strasbourg, France. Subjects Forty‐two women with low grade and high grade CIN, twenty women with cervical squamous cancer and twenty‐two women with normal cervix assessed by cytological, colposcopical and histological analysis. Methods Viral DNA was detected by PCR technique in colposcopically directed biopsies. Results The prevalence of HPV16 and/or HPV18 with HSV and/or HCMV was significantly higher in cancers (25%) or high grade CIN (29%) than in normal cervices (0%). On the contrary, when only HPV DNA was found, there was no significant difference between cancers (3O%). high grade CIN (29%) and normal cervices (9%). Conclusions The results support the hypothesis of a role of herpes viruses (HSV and HCMV) as cofactors in cervical carcinogenesis.