Premium
A case of hemophagocytic syndrome associated with B‐cell lymphoma
Author(s) -
Ando Iwao,
Okitsu Hiroshi,
Kukita Atsushi,
Kishino Satoshi,
Mizuguchi Kunio
Publication year - 1995
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.1995.tb00291.x
Subject(s) - medicine , hepatosplenomegaly , pathology , lymphoma , histiocyte , dermis , b cell lymphoma , infiltration (hvac) , cd20 , atypical lymphocyte , physics , disease , thermodynamics
A rare case of hemophagocytic syndrome (HPS) associated with B‐cell lymphoma is reported. A 38‐year old female with dyspnea and fever developed a subcutaneous nodule with purpuric erythema on her right thigh and consulted our department on September 2, 1991. The histologic picture of this nodule revealed a dense infiltration of atypical lymphocytes into the dermis and subcutaneous tissue. A surface marker study of these atypical cells were CD22, CD74, and HLA‐DR positive, indicating a B‐cell origin for these cells. Normal histiocytes phagocyting erythrocytes were mixed with the infiltrating cells. The patient also had pericardial effusion, liver dysfunction, hepatosplenomegaly, and bleeding tendencies. The diagnosis was HPS associated with B‐cell lymphoma. She died of DIC on November 8, 1991.