Premium
Raynaud's phenomenon with gangrene of the digits as the revealing sign of an antiphospholipid syndrome
Author(s) -
Fiallo Paolo,
Nunzi Enrico
Publication year - 1995
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.1995.tb00120.x
Subject(s) - medicine , gangrene , aspirin , sign (mathematics) , raynaud disease , antiphospholipid syndrome , dermatology , surgery , thrombosis , mathematical analysis , mathematics
We report the case of a 37‐year‐old woman who suffered for years of Raynaud's phenomenon associated with gangrene of digits. The patient displayed high levels of circulating antiphospholipid (aPL) antibodies, which on treatment with aspirin decreased significantly along with resolution of both Raynaud's phenomena and distal ischemic necrosis. To our knowledge this is the first report of an aPL syndrome featuring severe Raynaud's phenomenon as the only clinical sign. Possible pathogenetic correlations and the favourable therapeutic effect of aspirin are discussed.