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Autoantibody profile in cutaneous lupus erythematosus subsets: correlations between various autoantibodies of the same isotype
Author(s) -
Kroumpouzos Georgios,
Tosca Androniki,
Konstadoulakis Manoussos M.,
Avgerinou Georgia,
Varelzidis Antony,
Stratigos John
Publication year - 1994
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.1994.tb00088.x
Subject(s) - autoantibody , medicine , subacute cutaneous lupus erythematosus , isotype , systemic lupus erythematosus , immunology , lupus erythematosus , cardiolipin , serology , discoid lupus erythematosus , antibody , pathology , connective tissue disease , autoimmune disease , biology , monoclonal antibody , genetics , disease , phospholipid , membrane
The objective of the present study was an extensive analysis of the autoantibody profile in the most common subsets of cutaneous lupus erythematosus (LE), acute and subacute cutaneous lupus erythematosus (ACLE, SCLE) as well as discoid lupus, localized or disseminatus (DLE loc, DLE dis). Antibodies (Abs) against glomerular extracts, actin. myosin and cardiolipin were examined in the various cutaneous lupus subgroups, in addition to ANA and Abs against DNA, ENA and IgG (rheumatoid factor). Abs against glomerular extracts were detected mainly in ACLE and SCLE, whereas Abs against actin, myosin and cardiolipin were found in all cutaneous lupus subsets. The detailed record of the autoantibody profile helped in the serological differential diagnosis of the various cutaneous lupus subsets, suggesting also that SCLE and DLE dis are distinct subsets in the spectrum of cutaneous LE. Finally, correlations between autoantibodies of the same isotype were carried out, providing implications for regulation of autoantibody production.