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Pemphigoid gestationis
Author(s) -
Jenkins Rachel E.,
Shornick Jeff K.,
Black Martin M.
Publication year - 1993
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.1993.tb00031.x
Subject(s) - medicine , autoantibody , immunofluorescence , immune system , basement membrane , immunology , bullous pemphigoid , lamina lucida , antigen , placenta , pathology , antibody , pregnancy , fetus , biology , basal lamina , ultrastructure , genetics
PG is a rare autoimmune bullous dermatosis of pregnancy that is characterised by linear deposition of C3, and occasionally IgG 1 along the BMZ of lesional, perilesional and clinically normal skin when examined by direct immunofluorescence. Frequently there is a circulating IgG 1 autoantibody (PG factor) directed against a BMZ antigen that avidly binds complement. The aberrant expression of MHC class II molecules in the placenta is important in triggering the immune response against a glycoprotein of 180 kDa found in the lamina lucida of the basement membrane of the amnion which cross reacts with that in the skin. The deposition of immune reagents in the placentae in PG has been implicated in the placental dysfunction and impaired foetal outcome which has been shown to occur in PG, Al present immunofluorescence is the key to differentiating PG from other clinically similar diseases.