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Preferential solubilization behaviours and stability of some phenolic‐bearing essential oils formulated in different microemulsion systems
Author(s) -
Edris A. E.,
Malone C. F. R.
Publication year - 2012
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1468-2494.2012.00737.x
Subject(s) - microemulsion , chemistry , solubilization , chromatography , dilution , essential oil , pulmonary surfactant , biochemistry , physics , thermodynamics
Synopsis The solubilization behaviour of a number of essential oils ( EO s) containing volatile phenolic constituents was investigated in five different micellar solutions. These oils include clove bud ( E ugenia caryophyllata ), thyme ( T hymus serpyllum ) and oregano ( T hymus capitatus ). Ternary and pseudo‐ternary phase diagrams were constructed to assess the ability for microemulsion formation and dilutability of each system using non‐ionic surfactants. Results showed that T ween 20 ( T 20) was more suitable to solubilize these oils compared with T ween 80 ( T 80). Clove EO was found to be easily microemulsifiable compared with the other EO s, whereas oregano showed the least tendency to form a microemulsion. Particle sizes measured at different dilution lines ranged between 5.9 and 16.9 nm. The chemical composition of each EO was revealed by gas chromatography and was correlated with the observed solubilization behaviour. The presence of solubilization enhancers like poly‐ols and short‐chain alcohols improved solubilization of all EO s; however, establishment of new dilution lines was controlled by EO type. Physical stability assessment showed that all microemulsions were stable against alternate freeze/thaw cycles which extended for 1 week. On the contrary, each system showed different temperature sensitivity in the thermal stress assessment. The results of this investigation can be useful in fabrication of thermodynamically stable aqueous system carrying aromatic and bioactive phenolics for different applications in personal hygiene, cosmetic, fragrance and pharmaceutical products.