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Schinus terebinthifolius R addi extract and linoleic acid from P assiflora edulis synergistically decrease melanin synthesis in B 16 cells and reconstituted epidermis
Author(s) -
Jorge A. T. S.,
Arroteia K. F.,
Santos Í. A.,
Andres E.,
Medina S. P. H.,
Ferrari C. R.,
Lourenço C. B.,
Biaggio R. M. T. T.,
Moreira P. L.
Publication year - 2012
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1468-2494.2012.00736.x
Subject(s) - kojic acid , skin whitening , arbutin , tyrosinase , linoleic acid , chemistry , melanin , hyperpigmentation , cosmeceutical , biochemistry , biology , pharmacology , fatty acid , enzyme , active ingredient , microbiology and biotechnology
Synopsis Several treatments for skin whitening are available today, but few of them are completely adequate, especially owing to the carcinogenic potential attributed to classical drugs like hydroquinone, arbutin and kojic acid. To provide an alternative and safer technology for whitening, we developed two botanical compounds originated from B razilian biodiversity, an extract of S chinus terebinthifolius R addi and a linoleic acid fraction isolated from P assiflora edulis oil. The whitening effect of these compounds was assessed using biochemical assays and in vitro models including cellular assays and equivalent skin. The results showed that S . terebinthifolius R addi extract is able to reduce the tyrosinase activity in vitro , and the combination of this extract with linoleic acid is able to decrease the level of melanin produced by B 16 cells cultured with melanocyte‐stimulating hormone. Furthermore, melanin was also reduced in human reconstituted epidermis (containing melanocytes) treated with the compounds. The combination of the compounds may provide a synergistic positive whitening effect rather than their isolated use. Finally, we demonstrated that the performance of these mixed compounds is comparable to classical molecules used for skin whitening, as kojic acid. This new natural mixture could be considered an alternative therapeutic agent for treating hyperpigmentation and an effective component in whitening cosmetics.