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Preparation and characterization of carnauba wax nanostructured lipid carriers containing benzophenone‐3
Author(s) -
Lacerda S. P.,
Cerize N. N. P.,
Ré M. I.
Publication year - 2011
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1468-2494.2010.00626.x
Subject(s) - benzophenone , carnauba wax , zeta potential , chemistry , chemical engineering , aqueous solution , wax , particle size , homogenization (climate) , materials science , chromatography , organic chemistry , nanotechnology , nanoparticle , biodiversity , ecology , engineering , biology
Synopsis Nanostructured lipid carriers (NLCs) are potential active delivery systems based on mixtures of solid lipids and liquid oil. In this paper, aqueous dispersions of NLCs were prepared by a hot high‐pressure homogenization technique using carnauba wax as the solid lipid and isodecyl oleate as the liquid oil. The preparation and stability parameters of benzophenone‐3‐loaded NLCs have been investigated concerning particle size, zeta potential and loading capacity to encapsulate benzophenone‐3, a molecular sunscreen. The current investigation illustrates the effect of the composition of the lipid mixture on the entrapment efficiency, in vitro release and stability of benzophenone‐3‐loaded in these NLCs. A loading capacity of approximately 5% of benzophenone‐3 (m BZ‐3 /m lipids ) was characteristic of these systems.