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Suppression of the melanogenesis and cellular antioxidant activity in B16 melanoma cells
Author(s) -
Tsuda A.,
Horigome S.,
Yoshida I.,
Yamaguchi A.,
Kibune N.,
Kamibe T.,
Watai M.,
Ozawa J.,
Kume K.
Publication year - 2010
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1468-2494.2010.00618_5.x
Subject(s) - antioxidant , tyrosinase , catalase , chemistry , caffeic acid , melanin , biochemistry , inhibitory postsynaptic potential , enzyme , biology , endocrinology
The results of antioxidant activities by ORAC assay and CAA assay were evaluated for melanogenesis. Although the antioxidant activity by ORAC was not correlated with the melanogenesis, the samples which showed high antioxidant activity by CAA tended to suppress melanogenesis. Caffeic acid and Citrus depressa juice, which demonstrated inhibitory effects on mela‐nogenesis, had high antioxidant activities but no inhibitory effects on tyrosinase activity. In addition, they inhibited the melanogenesis which was increased by inhibition of catalase activity. These results may suggest that antioxidant activity by CAA can contribute to the suppression of melanogenesis in B16 melanoma.