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Abstracts: The effects of Coptis japonica root extract and its key component, berberine, on human subcutaneous adipocytes
Author(s) -
YashikiTohi Keiko,
Kiso Akinori,
Zhou Yan Yang,
Iwasaki Daigo,
Kambara Toshimitsu,
Mizutani Kenji
Publication year - 2010
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1468-2494.2010.00583_5.x
Subject(s) - berberine , coptis chinensis , lipolysis , adipocyte , japonica , adipose tissue , chemistry , subcutaneous tissue , coptis , traditional medicine , botany , medicine , biochemistry , biology , traditional chinese medicine , pathology , alternative medicine
pp.274–280 An increase of subcutaneous fat presses lymph vessels and blood vessels in skin tissues, and results in not only causing skin troubles such as skin sagging and swelling but also forming cellulite that makes bodylines worse. To expand further application of plant extracts to cosmetics, we focused on inhibitory effects of subcutaneous preadipocytes differentiation and facilitating lipolysis in adipocytes. In this study, in a screening test of a number of plant extracts, Coptis japonica root extract and its key component, berberine, showed potent inhibition of triglyceride accumulation and subcutaneous preadipocytes differentiation. Furthermore, Coptis japonica root extract and berberine down‐regulated the mRNA expression level of several differentiation factors derived from subcutaneous preadipocytes. Coptis japonica root extract and berberine in subcutaneous adipocytes facilitated lipolysis in mature adipocytes. Our study suggested that Coptis japonica root extract and its key component, berberine, is expected to be useful for slimming and related skin troubles such as skin sagging, swelling, cellulite, and so on.