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Optimization of preservatives in a topical formulation using experimental design
Author(s) -
Rahali Y.,
PenséLhéritier A.M.,
Mielcarek C.,
Bensouda Y.
Publication year - 2009
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1468-2494.2009.00520.x
Subject(s) - preservative , sorbic acid , benzoic acid , antimicrobial , chemistry , chromatography , food science , organic chemistry
Synopsis Optimizing the preservative regime for a preparation requires the antimicrobial effectiveness of several preservative combinations to be determined. In this study, three preservatives were tested: benzoic acid, sorbic acid and benzylic alcohol. Their preservative effects were evaluated using the antimicrobial preservative efficacy test (challenge‐test) of the European Pharmacopeia (EP). A D‐optimal mixture design was used to provide a maximum of information from a limited number of experiments. The results of this study were analysed with the help of the Design Expert ® software and enabled us to formulate emulsions satisfying both requirements A and B of the EP.