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The stabilization technology of superfine liposome
Author(s) -
Matsuo Masaki,
Hisamitsu Issei,
Sumida Yasushi
Publication year - 2009
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1468-2494.2007.00427_2.x
Subject(s) - liposome , particle size , chemical engineering , chemistry , peg ratio , micelle , particle (ecology) , ether , phase (matter) , chromatography , materials science , organic chemistry , biochemistry , oceanography , finance , aqueous solution , engineering , economics , geology
Generally, hydrophilic surfactants are added to make a small particle size liposome. However, there is a problem that a small particle size liposome causes a decrease of its capacity in the internal water phase, and it cannot function well enough as a capsule. Therefore we investigated the effect of various surfactants and lipids on superfine liposome. Firstly, we examined some hydrophilic surfactants which have different molecular structures to minimize the liposomes. PEG‐25 phytostanol ether was most effective to make particle size small among non‐ionic hydrophilic surfactants. However, as the particle size got smaller, its capacity in the internal water phase decreased, being transformed into the micelles. Secondly, we tried to increase the capacity of the internal water phase by adding the combined lipid into the liposome membrane. It was indicated that phytosterol had the potential to increase remarkably the internal water phase. As a result, we found that it's possible to make a liposome of a small particle size having a large capacity in the internal water phase by using both PEG‐25 phytostanol ether and phytosterol. Furthermore, the superiority of the liposome which consisted of the above ingredients in electrolyte‐resistance was confirmed.