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Stabilization and release profile of retinol and tocopherol with microcapsules based on chitosan
Author(s) -
Viladot JosepLluís,
Gómez Yolanda,
Asensio JuanAntonio,
Hernández Antonio,
De Moragas Maria,
Martínez Sílvia,
Gargano Salvatore
Publication year - 2008
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1468-2494.2007.00411_4.x
Subject(s) - coacervate , chitosan , chemistry , tocopherol , retinol , delivery system , homogeneous , chromatography , controlled release , polymer , chemical engineering , antioxidant , nanotechnology , vitamin e , vitamin , biochemistry , materials science , organic chemistry , biomedical engineering , physics , engineering , thermodynamics , medicine
The incorporation of unstable cosmetic actives such as retinol into formulations requires methods of stabilization to ensure their long‐term activity and efficacy. A delivery system entrapping lipophilic vitamins such as retinol and tocopherol based on chitosan coacervation with negative polymers is described in this paper. The microcapsules appear to be spherical with a narrow particle size distribution, not aggregated, and with a homogeneous surface. Microencapsulation with such a system prolongs the active's life in skin care O/W formulations by at least one order of magnitude in the tested formulas. Furthermore, the biodegradation profile of this delivery system is consistent with a sustained release profile in human epidermis.