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The effect of the type and the concentration of the lipophilic surfactant on the stability and release kinetics of the W/O/W multiple emulsions[Note 1. Part of this study was presented at the 20th ...]
Author(s) -
Özer Ö.,
Baloglu E.,
Ertan G.,
Muguet V.,
Yazan Y.
Publication year - 2000
Publication title -
international journal of cosmetic science
Language(s) - French
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1468-2494.2000.00049.x
Subject(s) - pulmonary surfactant , chemistry , kinetics , chromatography , monomer , swelling , aqueous two phase system , aqueous solution , chemical engineering , phase (matter) , emulsion , organic chemistry , polymer , biochemistry , physics , quantum mechanics , engineering
Synopsis Stable multiple emulsions that contain different lipophilic surfactants in the internal aqueous phase have been formulated. The multiple systems were assessed by evaluating several parameters such as macroscopic aspect, droplet size, percent release and accelerated stability under centrifugation or elevated temperature. The effect of polymeric and monomeric surfactants on the release mechanism and stability was examined. An excess of monomeric surfactant in the oil phase enhances the release rate and decreases stability. The release rate can be decreased by an increase of the lipophilic surfactant concentration. It appears that the more the oil globule swells, the less hydrosoluble drug is released. As a result a high swelling capacity is associated with better stability. Résumé Des émulsions multiples stables ont été mises au point dans lesquelles des différentes tensioactif lipophiles en différentes concentrations sont incorporés dans la phase aqueuse interne. Les aspects macroscopiques, la taille des globules, le rendement d’encapsulation, la stabilitéà la centrifugation et à différentes températures ont été optimisés. L’effet des tensioactifs polymères et monomères sur la libération et la stabilité a été envisagé. Le tensioactif monomère en excés aurait plutôt une action déstabilisante, et l’augmentation de la libération. La capacité de gonflement des globules huileux augmente et la libération du marqueur est ralentie. En consequénce, la stabilité croit parallélement à l’augmentation de la capacité de gonflement.