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Increased incidence of G uillain– B arré syndrome after surgery
Author(s) -
Gensicke H.,
Datta A. N.,
Dill P.,
Schindler C.,
Fischer D.
Publication year - 2012
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2012.03730.x
Subject(s) - medicine , incidence (geometry) , confidence interval , population , relative risk , group b , retrospective cohort study , guillain barre syndrome , surgery , pediatrics , physics , environmental health , optics
Background and purpose Antecedent surgery has been described to trigger Guillain/x96Barré syndrome (GBS), but its evidence is poor and based on case reports only. Methods We performed a retrospective analysis of 63 patients with GBS admitted to the U niversity H ospital B asel and U niversity C hildren's H ospital B asel from J anuary 2005 to D ecember 2010. We calculated and compared the incidences of post‐surgical and non‐exposed patients with GBS in the study population and those reported previously in literature. Results Six of 63 (9.5%) GBS cases had had a surgery within 6 weeks prior to GBS . The relative risk of developing GBS during the 6‐week period after surgery is 13.1 times higher than the normal incidence in the study population (95% confidence interval: 5.68, 30.3; P ≤ 0.0001), suggesting an attributable risk of 4.1 cases per 100 000 surgeries. In addition, the incidence of post‐surgical GBS is significantly higher than influenza vaccine‐associated GBS in the study population ( P = 0.01) as well as in comparison with previous reported vaccine‐associated GBS ( P ≤ 0.0001) and background incidences ( P ≤ 0.0001). Conclusion Surgery must be considered to be a potential risk factor for developing GBS .