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Association study of functional polymorphisms in serotonin transporter gene with temporal lobe epilepsy in Han Chinese population
Author(s) -
Li J.,
Lin H.,
Zhu X.,
Li L.,
Wang X.,
Sun W.,
Wu X.,
Liu A.,
Niu F.,
Wang Y.,
Liu Y.
Publication year - 2012
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2011.03521.x
Subject(s) - serotonin transporter , serotonergic , epilepsy , genotyping , temporal lobe , variable number tandem repeat , medicine , allele , polymorphism (computer science) , tandem repeat , genetics , genotype , serotonin , biology , gene , psychiatry , receptor , genome
Background and purpose: Serotoninergic dysfunction was reported to be involved in aetiology of temporal lobe epilepsy (TLE). Serotonin (5‐HT) is actively cleared from synaptic cleft by serotonin transporter (5‐HTT). We investigated the association between three common polymorphisms of 5‐HTT gene, which may influence gene expression or function, and risk for TLE. Methods: Three hundred and thirty‐four patients with TLE and four hundred and eighty‐seven non‐epileptic control subjects from Han Chinese origin were enrolled for the present study. Polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) method was used for genotyping. Results: 10‐repeat allele frequency of 17 bp variable number of tandem repeats in the second intron (5‐HTTVNTR) was moderately higher in patients with TLE than in controls (9.1% vs. 6.1%, P = 0.0187, OR = 1.55, 95%CI = 1.07–2.26). Conclusion: Our study suggested 10‐repeat allele of 5‐HTTVNTR may be associated with TLE susceptibility.