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Regional cortical thickness and cognitive functions in non‐demented Parkinson’s disease patients: a pilot study
Author(s) -
Pellicano C.,
Assogna F.,
Piras F.,
Caltagirone C.,
Pontieri F. E.,
Spalletta G.
Publication year - 2012
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2011.03465.x
Subject(s) - medicine , parkinson's disease , dementia , cognition , physical medicine and rehabilitation , neuroscience , disease , psychiatry , psychology
Background and purpose: The pathology of neuropsychological deficits in Parkinson’s disease (PD) is incompletely defined. Methods: We investigated cortical thickness and neuropsychological performances in non‐demented patients with PD and healthy controls. Results: Patients showed significant cortical thinning in right middle temporal and left fusiform cortices. Verbal memory performance was related with left fusiform thinning. Conclusions: Cognitive and cortical changes in non‐demented patients with PD are detectable and clearly related.