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Association of incompleteness of the anterior part of the circle of Willis with the occurrence of lacunes in the basal ganglia
Author(s) -
Miyazawa N.,
Shinohara T.,
Yamagata Z.
Publication year - 2011
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2011.03400.x
Subject(s) - circle of willis , medicine , odds ratio , confidence interval , posterior communicating artery , basal (medicine) , basal ganglia , magnetic resonance imaging , anatomy , cardiology , radiology , central nervous system , internal carotid artery , insulin
Background and purpose: This study investigated whether incompleteness of the anterior part of the circle of Willis affects the occurrence of lacunes in the basal ganglia. Methods: One thousand and seventy‐seven healthy individuals examined by magnetic resonance (MR) imaging and MR angiography were divided into eight subgroups according to our new classification. Results: Logistic regression analysis demonstrated that healthy individuals with incompleteness of the anterior circle of Willis had significantly higher frequency of lacunes [odds ratio (OR): 2.121, 95% confidence interval (CI): 1.477–3.108; or OR: 2.46, 95% CI: 1.377–4.384 in cases without or with fetal type posterior communicating artery, respectively] and higher numbers of lacunes ( P < 0.001 or P < 0.001 in cases without or with fetal type posterior communicating artery, respectively) compared to patients with complete circle of Willis. Conclusions: Incompleteness of the anterior part of the circle of Willis significantly affected the occurrence of lacunes.