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Sleep disorders in adult‐onset myotonic dystrophy type 1: a controlled polysomnographic study
Author(s) -
Romigi A.,
Izzi F.,
Pisani V.,
Placidi F.,
Pisani L. R.,
Marciani M. G.,
Corte F.,
Panico M. B.,
Torelli F.,
Uasone E.,
Vitrani G.,
Albanese M.,
Massa R.
Publication year - 2011
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2011.03352.x
Subject(s) - myotonic dystrophy , medicine , polysomnography , sleep onset , multiple sleep latency test , excessive daytime sleepiness , sleep (system call) , sleep disorder , somnolence , non rapid eye movement sleep , anesthesia , cardiology , audiology , physical therapy , insomnia , apnea , electroencephalography , psychiatry , computer science , operating system , adverse effect
Background: Sleep disturbances and excessive daytime somnolence are common and disabling features in adult‐onset myotonic dystrophy type 1 (DM1). Methods: Our study used questionnaires, ambulatory polysomnography and the multiple sleep latency test to evaluate sleep‐wake cycle and daytime sleepiness in unselected adult‐onset DM1 patients. We recruited 18 patients affected by adult‐onset DM1 and 18 matched controls. Results: Sleep efficiency was <90% in 16/18 patients, and it was significantly reduced when compared with controls. Reduced sleep efficiency was associated with abnormal respiratory events (5/18 patients) and/or periodic limb movements (11/18 patients). The Periodic Limb Movement Index was significantly increased in DM1 versus controls. A significantly lower mean MSLT sleep latency was detected in DM1 versus controls, but it did not reach pathological levels. Conclusions: Our controlled study demonstrated sleep alterations in unselected consecutive DM1 patients. Periodic limb movements in sleep are commonly associated with sleep disturbance in adult‐onset DM1, and it may represent a marker of CNS neurodegenerative processes in DM1.