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Lack of association of LINGO1 rs9652490 and rs11856808 SNPs with familial essential tremor
Author(s) -
LorenzoBetancor O.,
GarcíaMartín E.,
Cervantes S.,
Agúndez J. A. G.,
JiménezJiménez F. J.,
AlonsoNavarro H.,
Luengo A.,
Coria F.,
Lorenzo E.,
Irigoyen J.,
Pastor P.
Publication year - 2011
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2010.03251.x
Subject(s) - essential tremor , medicine , genotyping , single nucleotide polymorphism , genetic association , population , genome wide association study , genetics , psychiatry , genotype , gene , biology , environmental health
Background: Essential tremor (ET) is a frequent movement disorder with a substantial family aggregation. A genome‐wide association study has recently shown that LINGO1 gene variants are associated with increased risk of ET. Methods: We intended to replicate these findings by genotyping rs9652490 and rs11856808 in a series of 226 familial ET subjects and 1117 healthy controls from referral movement disorder clinics in Spain. Results: We were unable to replicate the association between LINGO1 variants and familial ET. Conclusions: Our results indicate that the LINGO1 variants analyzed are not a major risk factor for developing familial ET in our population, which suggests the existence of other unknown genetic risk factors responsible for familial ET in the Spanish population.