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Interleukin‐6 and silent cerebral infarction in hemodialysis patients: a cross‐sectional study
Author(s) -
Kikuchi H.,
Anan F.,
Kaneda K.,
Nawata T.,
Eshima N.,
Saikawa T.,
Yoshimatsu H.
Publication year - 2011
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2010.03226.x
Subject(s) - medicine , hemodialysis , odds ratio , uric acid , body mass index , logistic regression , gastroenterology , cross sectional study , diabetes mellitus , cerebral infarction , stroke (engine) , risk factor , cardiology , endocrinology , ischemia , pathology , mechanical engineering , engineering
Background: In patients with chronic renal failure undergoing hemodialysis (HD), silent cerebral infarctions (SCI) are associated with high mortality. Levels of interleukin‐6 (IL‐6) increase with renal dysfunction and may be a novel predictor for cerebrovascular events. We tested the hypothesis that increased IL‐6 levels correlate with the occurrence of SCI in HD patients. Methods: Using cranial magnetic resonance imaging findings, we divided 50 Japanese patients undergoing HD into two groups: with SCI (60 ± 7 years, mean ± SD, n = 27) and without SCI (60 ± 6 years, n = 23). We compared the gender, body mass index, metabolic profiles, IL‐6 levels, and smoking habits between the two groups. Results: We made the following observations: (i) The prevalence of diabetes or hypertension did not differ between the two groups, (ii) the level of IL‐6 was higher in the with‐SCI group than in the without‐SCI group ( P < 0.0001), (iii) the proportion of smokers was higher in the with‐SCI group ( P < 0.05), (iv) plasma level of high‐density lipoprotein cholesterol was lower, whilst uric acid level was higher, in the with‐SCI group ( P < 0.05 and P < 0.05, respectively), and (v) multiple logistic regression analysis identified IL‐6 levels as being significantly associated with the presence of SCI (odds ratio 3.13, 95% CI = 1.42–7.89, P < 0.0001). Conclusions: This study indicates that patients with chronic renal failure who are maintained on HD exhibit an increased prevalence of SCI and that IL‐6 is significantly associated with the presence of SCI in HD patients.