Premium
Effect of controlled‐release levodopa on the microstructure of sleep in Parkinson’s disease
Author(s) -
Wailke S.,
Herzog J.,
Witt K.,
Deuschl G.,
Volkmann J.
Publication year - 2011
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2010.03213.x
Subject(s) - levodopa , carbidopa , medicine , bedtime , parkinson's disease , dopaminergic , dopamine , sleep (system call) , anesthesia , disease , computer science , operating system
Background: Dopamine is an important neurotransmitter in the regulation of the sleep–wake cycle, and parkinsonian patients suffer from prominent sleep abnormalities. Hence, the question arises whether the disrupted sleep pattern in Parkinson’s disease (PD) is responsive to dopaminergic treatment. Methods: Thirty‐two patients (18 women, 45–82 years old; mean 61 ± 8 years) with dopamine‐responsive, akinetic‐rigid PD, not taking neuroleptic medication or suffering from dementia were randomized into two groups. Both groups had to withhold their usual dopaminergic medication after noon. At bedtime, one group received 200 mg controlled‐release (CR) levodopa/carbidopa, whilst the other group spent the night in the ‘off’‐state. Polysomnographic recordings were obtained in all patients and 16 age‐matched, healthy controls. Results: Compared to healthy controls, patients with PD suffered from significantly decreased total sleep time, REM sleep and slow wave sleep (SWS), whilst the time spent awake was increased. The administration of levodopa/carbidopa CR had no impact on any of these variables. Conclusion: Levodopa/carbidopa CR has previously been found effective for treating night‐time akinesia, but according to this study, it has no impact on the altered sleep structure in PD.