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Brain immunohistopathological study in a patient with anti‐NMDAR encephalitis
Author(s) -
Camdessanché J.P.,
Streichenberger N.,
Cavillon G.,
Rogemond V.,
Jousserand G.,
Honnorat J.,
Convers P.,
Antoine J.C.
Publication year - 2011
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2010.03180.x
Subject(s) - medicine , encephalitis , anti nmda receptor encephalitis , neuroscience , virology , virus , biology
Background and purpose: Anti‐ N ‐methyl‐ d ‐asparate (NMDA) receptor encephalitis is thought to be antibody‐mediated. To perform an immunohistopathological study of the inflammatory reaction in a brain biopsy performed before immunomodulatory treatments in a patient with anti‐NMDA receptor encephalitis. Methods: An immunohistochemical study was performed using CD3, CD68, CD20, CD138 and CD1a antibodies. Results: Prominent B‐cell cuffing was present around brain vessels accompanied by some plasma cells, while macrophages and T cells were scattered throughout the brain parenchyma. Conclusion: These findings suggest that the B cells interact with the T cells and are involved in antibody secretion by the plasma cells.