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Social consequences of multiple sclerosis: clinical and demographic predictors – a historical prospective cohort study
Author(s) -
Pfleger C. C. H.,
Flachs E. M.,
KochHenriksen N.
Publication year - 2010
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2010.03020.x
Subject(s) - medicine , disability pension , proportional hazards model , hazard ratio , prospective cohort study , age of onset , cohort , multiple sclerosis , pediatrics , physical therapy , disease , confidence interval , population , psychiatry , environmental health
Background: Time to disability pension is one of the endpoints to be used to determine the prognosis of multiple sclerosis (MS) in prospective studies. Objective: To assess the time to cessation of work and receiving disability pension in MS, and how it may depend on gender, type of work and age and symptom at onset. Method: A total of 2240 Danes with onset of definite/probable MS 1980–1989, identified from the Danish MS‐Registry, were included. Information on social endpoints was retrieved from Statistics Denmark. Cox regression analyses were used with onset as starting point. Results: Afferent onset symptoms [hazard ratio (HR 0.57)] and non‐physical type of work (HR 0.70) were favourable prognostic factors compared with high age at onset, physical work and efferent symptoms at onset. The mean time to disability pension was 13 years for patients with afferent/brainstem onset symptom but 8.7 years for those with efferent onset symptoms ( P < 0.0001). The effect of onset symptom was reduced and the effect of sex became significant when all covariates and age at onset were included in multivariate Cox regression. Conclusions: Onset age, type of onset symptom and work are robust predictors of disability pension in MS. Disability pension proves to be a reliable milestone in estimation of the prognosis of MS.