Premium
Cerebrospinal fluid hypocretin levels are normal in idiopathic REM sleep behaviour disorder
Author(s) -
Anderson K. N.,
Vincent A.,
Smith I. E.,
Shneerson J. M.
Publication year - 2010
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2010.02954.x
Subject(s) - medicine , cerebrospinal fluid , sleep (system call) , rem sleep behavior disorder , neuroscience , narcolepsy , neurology , polysomnography , psychiatry , electroencephalography , psychology , operating system , computer science
Background: Rapid eye movement (REM) sleep behaviour disorder (RBD) is a common sleep disorder that can be associated with a number of neurodegenerative conditions as well as with narcolepsy. Current diagnostic criteria require overnight polysomnography, and there are no other biomarkers available. The control of REM sleep is complex with a putative on/off switch within the brainstem activated, amongst other things, by hypocretinergic pathways from the lateral hypothalamus. Methods: Cerebrospinal fluid hypocretin levels were measured in five patients with idiopathic RBD. Results: Hypocretin levels were between 254 and 450 pg/ml and therefore within the normal range of >100 pg/ml. Conclusion: Hypocretin levels in patients with idiopathic RBD are normal.