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Side effects of anesthesia in DM2 as compared to DM1: a comparative retrospective study
Author(s) -
Kirzinger L.,
Schmidt A.,
Kornblum C.,
SchneiderGold C.,
Kress W.,
Schoser B.
Publication year - 2010
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2009.02942.x
Subject(s) - medicine , anesthesia , weakness , retrospective cohort study , nausea , abdomen , rhabdomyolysis , surgery , muscle weakness
Background and purpose: Myotonic dystrophy type 2 (DM2) is an adult‐onset progressive multisystem disease. There have been no reported risks for anesthesia in DM2. Methods: We assess the frequency, type, and severity of peri‐operative complications under general and local anesthesia in genetically proven DM2. A retrospective multicenter study was conducted. Results: Out of 320 DM2 patients, 134 participated by completing questionnaires (41, 88%), which were delivered by mail, and their clinical records were reviewed (class III evidence). A total of 121 patients had 340 operations in general anesthesia at an average age of 40.5 years (range 18–82); 132 (38.8%) general anesthesia were performed prior to DM2 onset, 187 (55.9%) after disease onset. A total of 212 (62.4%) of the interventions were performed without known DM2 diagnosis. In 120 (35.3%) interventions, DM2 was already diagnosed. The locations of surgery were lower abdomen (47%), peripheral extremities (46.8%), upper abdomen (3.8%), thorax (1.8%), and brain (0.6%). The overall frequency of severe complications was 0.6% (2 of 340). One incident was a post‐operative development of rhabdomyolysis, hyperthermia, muscle weakness and renal failure; the others, prolonged muscular weakness and renal failure. Minor complications related to a general anesthesia were reported by 27 participants (20.2%). In 116 patients (86.6%), 342 interventions were performed in regional anesthesia. Minor complications were reported by 20.2% participants such as nausea (6.7%), muscular weakness and pain (5.9%), prolonged anesthesia (5.2%), circulatory insufficiency (2.9%), and shortness of breath (2.9%). Conclusion: The overall lower risk seems to be predominantly related to the minor respiratory involvement in DM2, than in myotonic dystrophy type 1 (DM1).