Premium
Short‐ and long‐term effects of endurance training in patients with mitochondrial myopathy
Author(s) -
Jeppesen T. D.,
Dunø M.,
Schwartz M.,
Krag T.,
Rafiq J.,
Wibrand F.,
Vissing J.
Publication year - 2009
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2009.02660.x
Subject(s) - deconditioning , mitochondrial myopathy , medicine , mitochondrial dna , exercise intolerance , myopathy , endurance training , physical medicine and rehabilitation , physical therapy , cardiology , genetics , biology , gene , heart failure
Background and purpose: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations. Methods: The effect of 3 and 12 months training and 3–12 months deconditioning was studied in four patients carrying different mtDNA mutations. Results: Three‐month moderate‐intensity training increased oxidative capacity by 23%, which was sustained after 6–12 months of low‐intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle. Conclusion: Long‐term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.